CD200 Receptor Restriction of Myeloid Cell Responses Antagonizes Antiviral Immunity and Facilitates Cytomegalovirus Persistence within Mucosal Tissue
Identifieur interne : 000973 ( Main/Exploration ); précédent : 000972; suivant : 000974CD200 Receptor Restriction of Myeloid Cell Responses Antagonizes Antiviral Immunity and Facilitates Cytomegalovirus Persistence within Mucosal Tissue
Auteurs : Gabrielle Stack [Royaume-Uni] ; Emma Jones [Royaume-Uni] ; Morgan Marsden [Royaume-Uni] ; Maria A. Stacey [Royaume-Uni] ; Robert J. Snelgrove [Royaume-Uni] ; Paul Lacaze [Royaume-Uni] ; Laura C. Jacques [Royaume-Uni] ; Simone M. Cuff [Royaume-Uni] ; Richard J. Stanton [Royaume-Uni] ; Awen M. Gallimore [Royaume-Uni] ; Tracy Hussell [Royaume-Uni] ; Gavin W. G. Wilkinson [Royaume-Uni] ; Peter Ghazal [Royaume-Uni] ; Philip R. Taylor [Royaume-Uni] ; Ian R. Humphreys [Royaume-Uni]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2015.
Abstract
CD200 receptor (CD200R) negatively regulates peripheral and mucosal innate immune responses. Viruses, including herpesviruses, have acquired functional CD200 orthologs, implying that viral exploitation of this pathway is evolutionary advantageous. However, the role that CD200R signaling plays during herpesvirus infection
Url:
DOI: 10.1371/journal.ppat.1004641
PubMed: 25654642
PubMed Central: 4412112
Affiliations:
- Royaume-Uni
- Angleterre, Grand Londres, Grand Manchester, Écosse
- Londres, Manchester, Édimbourg
- Université d'Édimbourg, Université de Manchester
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Stacey</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Snelgrove, Robert J" sort="Snelgrove, Robert J" uniqKey="Snelgrove R" first="Robert J." last="Snelgrove">Robert J. Snelgrove</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lacaze, Paul" sort="Lacaze, Paul" uniqKey="Lacaze P" first="Paul" last="Lacaze">Paul Lacaze</name><affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Division of Pathway Medicine and Edinburgh Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Pathway Medicine and Edinburgh Infectious Diseases, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Jacques, Laura C" sort="Jacques, Laura C" uniqKey="Jacques L" first="Laura C." last="Jacques">Laura C. Jacques</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Cuff, Simone M" sort="Cuff, Simone M" uniqKey="Cuff S" first="Simone M." last="Cuff">Simone M. Cuff</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Stanton, Richard J" sort="Stanton, Richard J" uniqKey="Stanton R" first="Richard J." last="Stanton">Richard J. Stanton</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Gallimore, Awen M" sort="Gallimore, Awen M" uniqKey="Gallimore A" first="Awen M." last="Gallimore">Awen M. Gallimore</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Hussell, Tracy" sort="Hussell, Tracy" uniqKey="Hussell T" first="Tracy" last="Hussell">Tracy Hussell</name><affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>Manchester Collaborative Centre for Inflammation Research (MCCIR), University of Manchester, Manchester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Manchester Collaborative Centre for Inflammation Research (MCCIR), University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Wilkinson, Gavin W G" sort="Wilkinson, Gavin W G" uniqKey="Wilkinson G" first="Gavin W. G." last="Wilkinson">Gavin W. G. Wilkinson</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Ghazal, Peter" sort="Ghazal, Peter" uniqKey="Ghazal P" first="Peter" last="Ghazal">Peter Ghazal</name><affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Division of Pathway Medicine and Edinburgh Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Pathway Medicine and Edinburgh Infectious Diseases, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R." last="Taylor">Philip R. Taylor</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Humphreys, Ian R" sort="Humphreys, Ian R" uniqKey="Humphreys I" first="Ian R." last="Humphreys">Ian R. Humphreys</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea><wicri:noRegion>Cambridgeshire</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>CD200 receptor (CD200R) negatively regulates peripheral and mucosal innate immune responses. Viruses, including herpesviruses, have acquired functional CD200 orthologs, implying that viral exploitation of this pathway is evolutionary advantageous. However, the role that CD200R signaling plays during herpesvirus infection <italic>in vivo</italic> requires clarification. Utilizing the murine cytomegalovirus (MCMV) model, we demonstrate that CD200R facilitates virus persistence within mucosal tissue. Specifically, MCMV infection of CD200R-deficient mice (CD200R<sup>-/-</sup>) elicited heightened mucosal virus-specific CD4 T cell responses that restricted virus persistence in the salivary glands. CD200R did not directly inhibit lymphocyte effector function. Instead, CD200R<sup>-/-</sup> mice exhibited enhanced APC accumulation that in the mucosa was a consequence of elevated cellular proliferation. Although MCMV does not encode an obvious CD200 homolog, productive replication in macrophages induced expression of cellular CD200. CD200 from hematopoietic and non-hematopoietic cells contributed independently to suppression of antiviral control <italic>in vivo</italic>. These results highlight the CD200-CD200R pathway as an important regulator of antiviral immunity during cytomegalovirus infection that is exploited by MCMV to establish chronicity within mucosal tissue.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wright, Gj" uniqKey="Wright G">GJ Wright</name></author><author><name sortKey="Cherwinski, H" uniqKey="Cherwinski H">H Cherwinski</name></author><author><name sortKey="Foster Cuevas, M" uniqKey="Foster Cuevas M">M Foster-Cuevas</name></author><author><name sortKey="Brooke, G" uniqKey="Brooke G">G Brooke</name></author><author><name sortKey="Puklavec, Mj" uniqKey="Puklavec M">MJ Puklavec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barclay A, N" uniqKey="Barclay A N">N Barclay a</name></author><author><name sortKey="Wright, Gj" uniqKey="Wright G">GJ Wright</name></author><author><name sortKey="Brooke, G" uniqKey="Brooke G">G 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Fodor</name></author><author><name sortKey="Gibas, Cj" uniqKey="Gibas C">CJ Gibas</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Grand Manchester</li><li>Écosse</li></region><settlement><li>Londres</li><li>Manchester</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Manchester</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Stack, Gabrielle" sort="Stack, Gabrielle" uniqKey="Stack G" first="Gabrielle" last="Stack">Gabrielle Stack</name></noRegion><name sortKey="Cuff, Simone M" sort="Cuff, Simone M" uniqKey="Cuff S" first="Simone M." last="Cuff">Simone M. Cuff</name><name sortKey="Gallimore, Awen M" sort="Gallimore, Awen M" uniqKey="Gallimore A" first="Awen M." last="Gallimore">Awen M. Gallimore</name><name sortKey="Ghazal, Peter" sort="Ghazal, Peter" uniqKey="Ghazal P" first="Peter" last="Ghazal">Peter Ghazal</name><name sortKey="Humphreys, Ian R" sort="Humphreys, Ian R" uniqKey="Humphreys I" first="Ian R." last="Humphreys">Ian R. Humphreys</name><name sortKey="Humphreys, Ian R" sort="Humphreys, Ian R" uniqKey="Humphreys I" first="Ian R." last="Humphreys">Ian R. Humphreys</name><name sortKey="Hussell, Tracy" sort="Hussell, Tracy" uniqKey="Hussell T" first="Tracy" last="Hussell">Tracy Hussell</name><name sortKey="Jacques, Laura C" sort="Jacques, Laura C" uniqKey="Jacques L" first="Laura C." last="Jacques">Laura C. Jacques</name><name sortKey="Jones, Emma" sort="Jones, Emma" uniqKey="Jones E" first="Emma" last="Jones">Emma Jones</name><name sortKey="Lacaze, Paul" sort="Lacaze, Paul" uniqKey="Lacaze P" first="Paul" last="Lacaze">Paul Lacaze</name><name sortKey="Marsden, Morgan" sort="Marsden, Morgan" uniqKey="Marsden M" first="Morgan" last="Marsden">Morgan Marsden</name><name sortKey="Snelgrove, Robert J" sort="Snelgrove, Robert J" uniqKey="Snelgrove R" first="Robert J." last="Snelgrove">Robert J. Snelgrove</name><name sortKey="Stacey, Maria A" sort="Stacey, Maria A" uniqKey="Stacey M" first="Maria A." last="Stacey">Maria A. Stacey</name><name sortKey="Stanton, Richard J" sort="Stanton, Richard J" uniqKey="Stanton R" first="Richard J." last="Stanton">Richard J. Stanton</name><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R." last="Taylor">Philip R. Taylor</name><name sortKey="Wilkinson, Gavin W G" sort="Wilkinson, Gavin W G" uniqKey="Wilkinson G" first="Gavin W. G." last="Wilkinson">Gavin W. G. Wilkinson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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